Endothelial c-IAP2 Loss Amplifies P2X7 Receptor-Driven Inflammation and Worsens Infection-Associated Pulmonary Hypertension
ES Villarreal, Ygor Marinho, Omar Loya, Samuel Yaw Aboagye, DL Williams, Jun Sun, SERPIL CEM ERZURUM, Vinicio de Jesús Pérez, Suellen D. Oliveira
This study shows that loss of endothelial c-IAP2 worsens Sch-PH by amplifying P2X7R-driven inflammation and microvascular apoptosis.
bioRxiv · May 22, 2025 · PreprintPharmacology & Toxicology