Stearoyl-CoA Desaturases regulate stem and progenitor cell metabolism and function in response to nutrient abundance
Kubra B. Akkaya-Colak, Andrea R. Keller, Maria H. Festing, Khushboo Gupta, James Sledziona, Ayobami Adeniyi, Omar West, Patrick Stevens, Maciej Pietrzak, Sue E. Knoblaugh, Helaina Walesewicz, Dominique A. Baldwin, Judith Simcox, James Mukasa Ntambi, Steven K. Clinton, Maria M. Mihaylova
This study shows that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell metabolism and function in response to nutrient abundance, affecting tissue homeostasis and regeneration.
bioRxiv · Sep 17, 2025 · PreprintPhysiology