Maciej Pietrzak

This study shows that Caspase-11 worsens severe SARS-CoV-2 by increasing inflammation and reducing CD8 T-cell immunity, but its removal improves viral clearance and survival.

This study shows frontal brain injury reduces reward-predictive cue sensitivity and remodels the nucleus accumbens, leading to impaired decision-making and potential psychiatric symptoms.

This study shows that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell metabolism and function in response to nutrient abundance, affecting tissue homeostasis and regeneration.

This study uses an automated behavioral system and transcriptomic analysis to identify cognitive impairments in mice with long COVID, finding similar transcriptomic changes to humans.

This paper introduces foundational steps for analyzing spatial transcriptomic data from 10X Visium, focusing on clustering, spatially variable gene discovery, and cell-cell communication.

The paper identifies an enhancer, REN, that regulates gene expression during zebrafish heart regeneration by switching its target gene from adamts1 to runx1.

This study identifies DNA hypomethylation of CASP4 in AD microglia leading to increased CASP4 expression, which promotes neuroinflammation and amyloid-β deposition in Alzheimer's disease.

The paper examines inter-individual variability in human alveolar macrophage responses to Mycobacterium tuberculosis by analyzing gene and protein expression over time.