Author

Ondřej Cais

MRC Laboratory of Molecular Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2

Frequent Co-Authors

Danyang ZhangiD· 2 shared Ingo H. GregeriD· 2 shared Jake F. WatsoniD· 2 shared Bianka K. Kohegyi· 1 shared Peter M. MatthewsiD· 1 shared Remigijus LapėiD· 1 shared Saher Afshan ShaikhiD· 1 shared Terunaga NakagawaiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Danyang ZhangORCID

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2 papers

Recent·Most cited

Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics

Danyang Zhang, Remigijus Lapė, Saher Afshan Shaikh, Bianka K. Kohegyi, Jake F. Watson, Ondřej Cais, Terunaga Nakagawa, Ingo H. Greger

The paper investigates the modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics using cryo-EM structures, electrophysiology, and simulations, revealing ligand-dependent effects on receptor function.

bioRxiv · Sep 25, 2022 · PreprintNeuroscience

Gating transitions and modulation of a hetero-octameric AMPA glutamate receptor

Danyang Zhang, Jake F. Watson, Peter M. Matthews, Ondřej Cais, Ingo H. Greger

This study determines cryo-EM structures of a heteromeric AMPA receptor complex in different states, revealing how auxiliary subunits modulate gating and synaptic function.

Nature · Jun 2, 2021Peer-reviewedNeuroscience