Jake F. Watson

Hippocampal CA3 forms a two-layer network of molecularly distinct cell types in mice and humans

The paper identifies two molecularly distinct subtypes of CA3 pyramidal neurons in mice and humans, revealing their unique anatomical and functional roles in hippocampal circuits.

Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory

This study identifies unique connectivity and synaptic rules in human hippocampal CA3 circuits that enhance associative memory capacity compared to rodents.

'Mini analysis' is an unreliable reporter of synaptic changes

The paper shows that analyzing miniature postsynaptic currents (mPSCs) is unreliable for detecting synaptic changes due to incomplete detection and false confidence in results.

Cell-specific wiring routes information flow through hippocampal CA3

The paper revises the classical trisynaptic view of the hippocampus by showing CA3 pyramidal neurons form distinct subclasses with asymmetric connectivity and interneuron innervation.

Saturated reconstruction of living brain tissue

This paper introduces a method for saturated reconstruction of living brain tissue using advanced imaging and deep learning to achieve high-resolution, volumetric analysis of neural structures over time.

Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics

The paper investigates the modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics using cryo-EM structures, electrophysiology, and simulations, revealing ligand-dependent effects on receptor function.

Uncovering brain tissue architecture across scales with super-resolution light microscopy

The paper introduces CATS, a method to map brain tissue architecture across scales, demonstrating its application to hippocampal mossy fiber circuitry.

AMPA receptor anchoring at CA1 synapses is determined by an interplay of N-terminal domain and TARP γ8 interactions

The paper investigates how AMPA receptor anchoring at CA1 synapses is regulated by interactions between the N-terminal domain and TARP γ8, showing both are crucial for maintaining synaptic transmission.

Gating transitions and modulation of a hetero-octameric AMPA glutamate receptor

This study determines cryo-EM structures of a heteromeric AMPA receptor complex in different states, revealing how auxiliary subunits modulate gating and synaptic function.

An inhalation anaesthesia approach for neonatal mice allowing streamlined stereotactic injection in the brain

The paper develops an inhalation anaesthesia method for neonatal mice to enable streamlined stereotactic brain injections for transduction and modification of tissue.