IL-32 drives inflammatory responses in IFN-γ primed human macrophages via a Myddosome-dependent pathway and is elevated in COVID-19
Ana Ramón-Vázquez, Agnieszka Skowyra, Tadhg Crowley, Janaki Velmurugan, Ciaran M. Lee, Andrew J. Lindsay, Jerzy A. Woznicki, Panagiota Stamou, Ornella Nelson, Ian B. Jeffery, Amanda J. Lohan, Werner C. Albrich, Liam O’Mahony, Silvia Melgar, Fergus Shanahan, , Kenneth Nally
This study identifies IL-32β as a ligand that primes human macrophages for M1-like inflammatory responses via a Myddosome-dependent pathway and shows elevated IL-32 in severe COVID-19.
bioRxiv · May 29, 2025 · PreprintImmunology