Author

Bradford L. McRae

Janssen Research & Development (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Agnieszka SkowyraiD· 1 shared Amanda J. LohaniD· 1 shared Ana Ramón-Vázquez· 1 shared Andrew J. LindsayiD· 1 shared Ciaran M. LeeiD· 1 shared Daniel M. Horowitz· 1 shared Darren RuaneiD· 1 shared Dylan Richards· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Agnieszka SkowyraORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Immune signaling mediates stromal changes to support epithelial reprogramming in Celiac duodenum

Dylan Richards, Klebea Sohn, Shrikanth Chomanahalli Basavarajappa, Daniel M. Horowitz, Joshua James Rusbuldt, Lynn Tomsho, Kate Paget, Ivan Chavez, Koen Van den Berge, Bradford L. McRae, Heather Loughnane, Séamus Hussey, Patrick T. Walsh, Darren Ruane

This study identifies immune-stromal-epithelial communication in CeD duodenum using scRNA-seq, revealing fibroblast-mediated epithelial reprogramming through IL-1β and IFN-γ signals.

Cell Reports · Jul 21, 2025Peer-reviewedImmunology

IL-32 drives inflammatory responses in IFN-γ primed human macrophages via a Myddosome-dependent pathway and is elevated in COVID-19

Ana Ramón-Vázquez, Agnieszka Skowyra, Tadhg Crowley, Janaki Velmurugan, Ciaran M. Lee, Andrew J. Lindsay, Jerzy A. Woznicki, Panagiota Stamou, Ornella Nelson, Ian B. Jeffery, Amanda J. Lohan, Werner C. Albrich, Liam O’Mahony, Silvia Melgar, Fergus Shanahan, , Kenneth Nally

This study identifies IL-32β as a ligand that primes human macrophages for M1-like inflammatory responses via a Myddosome-dependent pathway and shows elevated IL-32 in severe COVID-19.

bioRxiv · May 29, 2025 · PreprintImmunology