Tumor-specific draining lymph node CD8 T cells orchestrate an anti-tumor response to neoadjuvant PD-1 immune checkpoint blockade
Rachel Honigsberg, Tatiana Cruz, Liron Yoffe, Meixian Stephanie Tang, Ozge Dicle, Geoffrey J. Markowitz, Marissa M. Michael, Arshdeep Singh, Nasser Khaled Altorki, Olivier Elemento, Jonathan Villena‐Vargas
This study identifies two transcriptionally distinct CD8 T cell populations in tumor-draining lymph nodes that are shaped by neoadjuvant chemoimmunotherapy and influence tumor and blood T cell environments.
bioRxiv · Apr 27, 2025 · PreprintCancer Biology