Nasser Khaled Altorki

JAK1/2 Inhibition Delays Cachexia and Improves Survival through Increased Food Intake

This study shows that JAK1/2 inhibition with ruxolitinib improves survival and body weight in lung cancer models by increasing food intake and restoring metabolic function.

Propionate metabolism dysregulation promotes drug-tolerant persister cell survival in non-small cell lung cancer

This study shows that propionate metabolism dysregulation, through MMA accumulation and EMT activation, promotes drug-tolerant persister cell survival in NSCLC.

Tumor-draining lymph node derived CD8 T cells sustain durable systemic immunity after neoadjuvant IL-15 and PD-1 blockade

Neoadjuvant IL-15 with PD-1 blockade expands lymph node clonal diversity and preserves stem-like CD8 T cell features, yielding superior antitumor efficacy, durable memory, and reduced metastatic recurrence.

Paired plus-minus sequencing is an ultra-high throughput and accurate method for dual strand sequencing of DNA molecules

This paper introduces ppmSeq, a sequencing technology that improves accuracy and efficiency in detecting SNVs by sequencing both DNA strands, showing superior performance in clinical applications like ctDNA detection.

Tumor-specific draining lymph node CD8 T cells orchestrate an anti-tumor response to neoadjuvant PD-1 immune checkpoint blockade

This study identifies two transcriptionally distinct CD8 T cell populations in tumor-draining lymph nodes that are shaped by neoadjuvant chemoimmunotherapy and influence tumor and blood T cell environments.

Pan-Cancer PDOs Preserve Tumor Heterogeneity and Uncover Therapeutic Vulnerabilities

This study develops a pan-cancer PDO platform to preserve tumor heterogeneity and identify therapeutic vulnerabilities, finding that 58% of PDOs respond to Talazoparib and combination screens reveal resistance-overcoming drugs.

Simultaneous immunomodulation and epithelial-to-mesenchymal transition drives lung adenocarcinoma progression

This study profiles early-stage lung adenocarcinoma using multiplexed imaging mass cytometry to reveal two progression pathways: inflammation-driven and fibrosis-driven, with EMT masking malignant cell expansion.

Acquisition of discrete immune suppressive barriers contributes to the initiation and progression of preinvasive to invasive human lung cancer.

This study identifies immune suppressive barriers in preinvasive lung cancer progression using single-cell analyses, revealing key cellular and spatial changes that could inform therapeutic strategies.

Machine learning guided signal enrichment for ultrasensitive plasma tumor burden monitoring

This paper introduces MRD-EDGE, a machine learning platform for ultrasensitive ctDNA detection in plasma WGS, showing improved sensitivity and broader applicability for MRD monitoring.

Whole genome error-corrected sequencing for sensitive circulating tumor DNA cancer monitoring

This study applies low-cost whole genome sequencing to detect circulating tumor DNA at high sensitivity in plasma samples, achieving error rates as low as 10^-7 and enabling cancer monitoring without matched tumor sequencing.