Author

P. A. Champion

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:zebrafish· 2

Frequent Co-Authors

K. R. Nicholson· 3 shared R. M. Cronin· 3 shared A. R. Menon· 2 shared B. S. Jones· 2 shared D. D. Hu· 2 shared D. M. Tobin· 2 shared M. Champion· 2 shared M. K. Jennisch· 2 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

K. R. Nicholson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinum

K. R. Nicholson, R. M. Cronin, R. J. Prest, A. R. Menon, Y. Yang, M. K. Jennisch, M. Champion, D. M. Tobin, P. A. Champion

This study identifies EspN as a critical transcription factor regulating the ESX-1 system in M. marinum, which is essential for macrophage infection and disease burden, but its activity is masked by EspM under laboratory conditions.

bioRxiv · Jan 9, 2024Microbiology

The loss of the PDIM/PGL virulence lipids causes differential secretion of ESX-1 substrates in Mycobacterium marinum

B. S. Jones, D. D. Hu, K. R. Nicholson, R. M. Cronin, M. Champion, P. A. Champion

This study shows that loss of PDIM and PGL lipids in M. marinum reduces specific ESX-1 substrate secretion, impacting pathogenesis.

bioRxiv · Jan 9, 2024 · PreprintMicrobiology

An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.

O. A. Collars, B. S. Jones, D. D. Hu, S. D. Weaver, M. M. Champion, P. A. Champion

This study identifies Emp1 as the N-acetyltransferase responsible for EsxA acetylation in Mycobacterium marinum, showing its role in virulence and macrophage cytolysis.

bioRxiv · Mar 14, 2023 · PreprintMicrobiology

The EspN transcription factor is an infection-dependent regulator of the ESX-1 system in M. marinum

K. R. Nicholson, R. M. Cronin, A. R. Menon, M. K. Jennisch, D. M. Tobin, P. A. Champion

This study identifies EspN as an infection-dependent transcription factor that regulates ESX-1 gene expression during mycobacterial infection, but not under standard lab conditions.

bioRxiv · Feb 15, 2023 · PreprintMicrobiology

Mycobacterium tuberculosis SecA2-dependent activation of host Rig-I/MAVs signaling is not conserved in Mycobacterium marinum

L. G. Serene, P. A. Champion, J. S. Schorey

The paper investigates whether Mycobacterium tuberculosis SecA2-dependent activation of host Rig-I/MAVS signaling is conserved in Mycobacterium marinum and finds it is not.

bioRxiv · Jan 27, 2023 · PreprintMicrobiology