The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinum
K. R. Nicholson, R. M. Cronin, R. J. Prest, A. R. Menon, Y. Yang, M. K. Jennisch, M. Champion, D. M. Tobin, P. A. Champion
This study identifies EspN as a critical transcription factor regulating the ESX-1 system in M. marinum, which is essential for macrophage infection and disease burden, but its activity is masked by EspM under laboratory conditions.
bioRxiv · Jan 9, 2024Microbiology