A Drosophila in vivo chemical screen reveals that combination drug treatment targeting MEK and DGKα mitigates Ras-driven polarity-impaired tumourigenesis.
H. E. Richardson, J. E. La Marca, R. W. Ely, S. T. Diepstraten, P. Burke, G. L. Kelly, P. O. Humbert
This paper identifies a combination of MEK and DGKα inhibitors that reduces Ras-driven tumourigenesis in Drosophila and human cells.
bioRxiv · Mar 14, 2022 · PreprintCancer Biology