Author

P. O. Humbert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Assay:structural biology· 3 Research Focus:development & morphogenesis· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:Drosophila· 1

Frequent Co-Authors

M. Kvansakul· 3 shared B. Z. Stewart· 2 shared S. Caria· 2 shared A. H. Allam· 1 shared A. S. Chann· 1 shared G. L. Kelly· 1 shared H. E. Richardson· 1 shared J. E. La Marca· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiochemistry

M. Kvansakul

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural analysis of human papillomavirus E6 interactions with Scribble PDZ domains

B. Z. Stewart, S. Caria, P. O. Humbert, M. Kvansakul

This study identifies the Scribble PDZ1 and PDZ3 domains as key interactors of HPV E6 proteins and determines their structural interactions with E6 PBM motifs from high-risk HPV strains.

bioRxiv · Oct 12, 2022Biochemistry

E-cadherin in developing murine T cells controls spindle alignment and differentiation during β-selection

M. Charnley, A. H. Allam, L. M. Newton, P. O. Humbert, S. M. Russell

This study shows E-cadherin in murine T cells helps align the mitotic spindle and supports differentiation during β-selection by influencing immunological synapse formation.

bioRxiv · Jun 14, 2022 · PreprintCell Biology

A Drosophila in vivo chemical screen reveals that combination drug treatment targeting MEK and DGKα mitigates Ras-driven polarity-impaired tumourigenesis.

H. E. Richardson, J. E. La Marca, R. W. Ely, S. T. Diepstraten, P. Burke, G. L. Kelly, P. O. Humbert

This paper identifies a combination of MEK and DGKα inhibitors that reduces Ras-driven tumourigenesis in Drosophila and human cells.

bioRxiv · Mar 14, 2022 · PreprintCancer Biology

A Scribble-E-cadherin complex controls daughter cell patterning by multiple mechanisms

A. S. Chann, Y. Chen, T. Kinwel, P. O. Humbert, S. Russell

This study identifies how the Scribble-E-cadherin complex regulates daughter cell positioning through multiple mechanisms involving spindle orientation and junction formation.

bioRxiv · Apr 15, 2021 · PreprintCell Biology

Structural basis of the human Scribble-Vangl2 association in health and disease

J. Y. How, R. Stephens, K. Y. B. Lim, P. O. Humbert, M. Kvansakul

This study determines the crystal structures of Scribble PDZ domains bound to Vangl2 and shows how mutations disrupt interactions with multiple signaling regulators.

bioRxiv · Oct 7, 2020Cell Biology

Structural analysis of phosphorylation-associated interactions of MCC to Scribble PDZ domains

S. Caria, B. Z. Stewart, P. O. Humbert, M. Kvansakul

The paper investigates how phosphorylation affects Scribble PDZ domains' interactions with MCC, showing that phosphorylation at the -1 Ser position has limited impact on binding.

bioRxiv · Dec 19, 2018Biochemistry