Author

P. C. Boddu

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Cancer Biology· 1

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1

Frequent Co-Authors

A. K. Gupta· 1 shared A. K. Verma· 1 shared A. Olazabal Herrero· 1 shared B. De La Pena Avalos· 1 shared D. King· 1 shared E. Dray· 1 shared G. Kupfer· 1 shared H. Lin· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. K. Gupta

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1 paper

Recent·Most cited

Transcription elongation defects link oncogenic splicing factor mutations to targetable alterations in chromatin landscape

P. C. Boddu, A. K. Gupta, R. Roy, B. De La Pena Avalos, A. Olazabal Herrero, N. Neuenkirchen, J. T. Zimmer, N. S. Chandhok, D. King, Y. Nannya, S. Ogawa, H. Lin, M. D. Simon, E. Dray, G. Kupfer, , M. M. Pillai

This paper shows that mutations in SF3B1 and U2AF1 cause transcription elongation defects leading to chromatin changes and identifies targeting the Sin3/HDAC complex as a potential therapy.

bioRxiv · Feb 25, 2023Cancer Biology