S. Ogawa

The minimal SUF system can substitute for the canonical iron-sulfur cluster biosynthesis systems by using inorganic sulfide as the sulfur source.

Erythroid differentiation intensifies RNA mis-splicing in SF3B1-mutant myelodysplastic syndromes with ring sideroblasts

This study investigates SF3B1-mutant myelodysplastic syndromes with ring sideroblasts by isolating RS and analyzing their development and mis-splicing during erythroid differentiation.

Transcription elongation defects link oncogenic splicing factor mutations to targetable alterations in chromatin landscape

This paper shows that mutations in SF3B1 and U2AF1 cause transcription elongation defects leading to chromatin changes and identifies targeting the Sin3/HDAC complex as a potential therapy.

Viscoelastic Notch Signaling Hydrogel Induces Liver Bile Duct Organoid Growth and Morphogenesis

The paper develops a viscoelastic hydrogel that promotes liver bile duct organoid growth by modulating YAP signaling and Notch activation.

Porcine placenta extract upregulates ceramide synthase 3 expression via the PPARδ/ILK/Akt/mTOR/STAT3 pathway

This study identifies the PPARδ/ILK/Akt/mTOR/STAT3 pathway as the mechanism by which porcine placenta extract upregulates ceramide synthase 3 expression in HaCaT cells.

Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T cell lymphoma

The paper identifies MYCN overexpression in PTCL and shows EZH2 as a transcriptional co-factor for MYCN-driven gene activation, with therapeutic implications for HDAC inhibitors.

Strigolactones are chemoattractants for host tropism in Orobanchaceae parasitic plants

This study identifies strigolactones as chemoattractants guiding host tropism in parasitic Orobanchaceae plants.

T cell-intrinsic vitamin A metabolism and its signaling are targets for memory T cell-based cancer immunotherapy

This study identifies vitamin A metabolism and its signaling as regulators of memory T cell differentiation and shows their potential as targets for cancer immunotherapy.

AngioPlate - Biofabrication of perfusable complex tissues in multi-well plates with 4D subtractive manufacturing

The paper introduces a 4D subtractive manufacturing technique to create perfusable complex tissues in multi-well plates, enabling the fabrication of vascular networks and organ-specific structures.

Generation of functional ciliates cholangiocytes from human pluripotent stem cells

This study generates functional cholangiocytes from human pluripotent stem cells that exhibit mature characteristics and can be used for drug testing and disease modeling.

Combined landscape of single-nucleotide variants and copy-number alterations in clonal hematopoiesis

The paper combines SNVs/indels and CNAs analysis in CH to show their co-occurrence and impact on health outcomes.

Subtilase activity in the intrusive cells mediates haustorium maturation in parasitic plants

The study identifies subtilase activity in intrusive cells as critical for haustorium development and auxin-mediated host-parasite connections in Phtheirospermum japonicum.

Host-parasite tissue adhesion by a secreted type of β-1,4-glucanase in the parasitic plant Phtheirospermum japonicum

This study identifies a secreted β-1,4-glucanase gene involved in tissue adhesion between parasitic plants and hosts, revealing molecular similarities between parasitism and grafting.

Establishment of an orthodontic retention mouse model and the effect of anti-c-Fms antibody on orthodontic relapse

This study establishes a mouse orthodontic retention model and shows that longer retention and anti-c-Fms antibody reduce orthodontic relapse.

Decreased RORC expression and downstream signaling in HTLV-1-associated Adult T-cell Lymphoma/Leukemia uncovers an antiproliferative IL17 link: a potential target for immunotherapy?

The paper identifies decreased RORC expression and downstream antiproliferative IL17 signaling in ATL, suggesting therapeutic potential for boosting RORC/IL17 signaling.