Author

P. Chandrasegaran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Assay:scRNA-seq· 4 Research Focus:cell-cell communication· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2

Frequent Co-Authors

A. MacLeod· 4 shared J. F. Quintana Alcala· 3 shared J. Ogunsola· 3 shared M. C. Sinton· 3 shared A. Cooper· 2 shared D. M. Ngoyi· 2 shared L. de Lecea· 2 shared N. A. Mabbott· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersImmunology

A. MacLeod

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Author profile →

4 papers

Recent·Most cited

IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection

M. C. Sinton, P. Chandrasegaran, P. Capewell, A. Cooper, A. Girard, J. Ogunsola, G. Perona-Wright, D. Ngoyi, N. Kuispond, B. BUCHETON, M. Camara, S. Kajimura, C. Benezech, A. MacLeod, J. F. Quintana Alcala

Nature Communications · Nov 3, 2023Peer-reviewedImmunology

The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection

J. F. Quintana Alcala, M. C. Sinton, P. Chandrasegaran, L. K. Dubey, J. Ogunsola, M. A. Samman, M. Haley, G. McConnell, N. R. Kuispond Swar, D. M. Ngoyi, D. Bending, L. de Lecea, A. MacLeod, N. A. Mabbott

This study shows that chronic Trypanosoma brucei infection in mice causes meningeal lymphoid aggregates with autoreactive B cells and autoantibodies against brain antigens.

bioRxiv · Apr 30, 2023 · PreprintImmunology

Spatially-resolved single cell transcriptomics reveal a critical role for γδ T cells in the control of skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection

J. F. Q. Alcala, M. C. Sinton, P. Chandrasegaran, A. N. Lestari, R. Heslop, B. Cheaib, J. Ogunsola, D. M. Ngoyi, N. R. K. Swar, A. Cooper, S. B. Coffelt, A. MacLeod

This study uses spatial and single-cell transcriptomics to show that γδ T cells and adipocytes collaborate to control skin inflammation and adipose tissue wasting during chronic Trypanosoma brucei infection.

bioRxiv · Mar 1, 2023 · PreprintImmunology

Integrative single cell and spatial transcriptomic analysis reveal reciprocal microglia - plasma cell crosstalk in the mouse brain during chronic Trypanosoma brucei infection

J. F. Quintana Alcala, P. Chandrasegaran, M. Sinton, E. M. Briggs, T. D. Otto, R. Heslop, C. Bentley-Abbot, C. Loney, L. de Lecea, N. A. Mabbott, A. MacLeod

This study uses single cell and spatial transcriptomics to identify microglia-plasma cell interactions in the mouse brain during chronic T. brucei infection.

bioRxiv · Mar 25, 2022 · PreprintPathology