IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection
M. C. Sinton, P. Chandrasegaran, P. Capewell…·J. F. Quintana Alcala
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4 papers
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M. C. Sinton, P. Chandrasegaran, P. Capewell…·J. F. Quintana Alcala
J. F. Quintana Alcala, M. C. Sinton, P. Chandrasegaran…·N. A. Mabbott
This study shows that chronic Trypanosoma brucei infection in mice causes meningeal lymphoid aggregates with autoreactive B cells and autoantibodies against brain antigens.
J. F. Quintana Alcala, P. Chandrasegaran, M. Sinton…·A. MacLeod
This study uses single cell and spatial transcriptomics to identify microglia-plasma cell interactions in the mouse brain during chronic T. brucei infection.
J. F. Quintana Alcala, J. A. Bueren-Calabuig, F. Zuccotto…·M. C. Field
The paper shows that instability of TbAQP2 contributes to drug resistance in Trypanosoma brucei by affecting its folding, oligomerization, and localization.