The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity
S. M. Ahmed, P. D. Ramani, S. Q. R. Wong, X. Zhao, R. Ivanyi-Nagy, T. C. Leong, C. Chua, Z. Li, H. Hentze, I. B. Tan, J. Yan, R. DasGupta, P. Droge
This paper identifies HMGA2 as a regulator of DNA supercoiling and replication fork stability, showing its protective role against DNA damage from topoisomerase poisons and its potential as a therapeutic marker in cancer.
bioRxiv · Feb 8, 2019Cancer Biology