Author

H. Hentze

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

K. Ethirajulu· 2 shared A. D. T. Barrett· 1 shared A. P. C. Lim· 1 shared B. H. Gan· 1 shared B. J. Hanson· 1 shared B. Young· 1 shared C. Chua· 1 shared C. E. Z. Chan· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

K. Ethirajulu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pharmacodynamic evaluation of AUM001/tinodasertib, an oral inhibitor of mitogen-activated protein kinase (MAPK)-interacting protein kinase 1, 2 (MNK1/2) in preclinical models and tissues from a Phase 1 clinical study

B. H. Gan, L. H. Lee, R. Takeda, M. Yasin, V. Teneggi, K. Ethirajulu, P. Yeo, D. Umrani, V. Pendharkar, D. W. T. Lim, G. Li, Q. Lu, Y. Cao, R. Nellore, S. Blanchard, , V. Novotny-Diermayr

This paper evaluates the pharmacodynamic effects of AUM001/tinodasertib in preclinical models and human tissues from a Phase 1 study, showing dose-dependent inhibition of eIF4E phosphorylation in tumors and PBMCs.

bioRxiv · Feb 23, 2024 · PreprintCancer Biology

The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody

C. E. Z. Chan, S. G. K. Seah, D. H. Chye, S. Massey, M. Torres, A. P. C. Lim, S. K. K. Wong, J. J. Y. Neo, P. S. Wong, J. H. Lim, G. S. L. Loh, D. L. Wang, J. D. Boyd-Kirkup, S. Guan, D. Thakkar, , B. J. Hanson

The paper identifies SC31, a potent SARS-CoV-2 neutralizing antibody, and shows that its Fc-mediated effector functions are critical for its therapeutic efficacy in vivo.

bioRxiv · Oct 26, 2020Microbiology

The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity

S. M. Ahmed, P. D. Ramani, S. Q. R. Wong, X. Zhao, R. Ivanyi-Nagy, T. C. Leong, C. Chua, Z. Li, H. Hentze, I. B. Tan, J. Yan, R. DasGupta, P. Droge

This paper identifies HMGA2 as a regulator of DNA supercoiling and replication fork stability, showing its protective role against DNA damage from topoisomerase poisons and its potential as a therapeutic marker in cancer.

bioRxiv · Feb 8, 2019Cancer Biology