Author

I. B. Tan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Gan· 1 shared A. HEIT· 1 shared A. Jacobsen Skanderup· 1 shared A. Tan· 1 shared B. Madan· 1 shared C. Chia· 1 shared C. Chua· 1 shared C. W. Chua· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperMolecular Biology

A. Gan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/beta-catenin to RTK/MAPK signaling

B. Madan, S. R. Wadia, S. Patnaik, N. P. Harmston, E. J. Tan, I. B. Tan, D. W. Nes, E. G. Petretto, D. M. Virshup

This paper identifies FAXDC2 as a cholesterol biosynthesis enzyme that links Wnt/beta-catenin to RTK/MAPK signaling, showing its role in cancer progression and cellular differentiation.

bioRxiv · Dec 15, 2023Cancer Biology

A transcriptome-wide meta-analysis reveals lack of cancer-cell intrinsic determinants of response to immune checkpoint blockade

Y. A. Guo, T. Kulshrestha, M. M. Chang, I. Kassam, E. Revkov, S. Rizzetto, A. Tan, D. Tan, I. B. Tan, A. Jacobsen Skanderup

This study performs a transcriptome-wide meta-analysis to identify determinants of immune checkpoint blockade response, finding that stromal factors, not cancer-cell intrinsic features, are key predictors across tumor types.

bioRxiv · Jul 30, 2023 · PreprintCancer Biology

Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct

y. SIMONI, S. LI, S. ZHUANG, A. HEIT, S.-L. KOO, I.-T. CHOW, W. W. KWOK, I. B. TAN, D. S. W. TAN, E. W. NEWELL

The paper identifies bystander CD4+ T cells in human tumors, showing they are phenotypically distinct and express CD39, correlating with CD8+ TILs specific for non-cancer antigens.

bioRxiv · Jul 15, 2020 · PreprintImmunology

The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity

S. M. Ahmed, P. D. Ramani, S. Q. R. Wong, X. Zhao, R. Ivanyi-Nagy, T. C. Leong, C. Chua, Z. Li, H. Hentze, I. B. Tan, J. Yan, R. DasGupta, P. Droge

This paper identifies HMGA2 as a regulator of DNA supercoiling and replication fork stability, showing its protective role against DNA damage from topoisomerase poisons and its potential as a therapeutic marker in cancer.

bioRxiv · Feb 8, 2019Cancer Biology

Liquid biopsy in gastrointestinal stromal tumors -- Simultaneous detection of primary and secondary mutations with an NGS based circulating tumor DNA assay

N. Somasundaram, R. Quek, D. Ho, M. F. B. Harunal Ras, R. R. J. Lim, A. Gan, W. L. Tan, J. Y. Chan, E. Poon, C. W. Chua, J. Ong, C. Chia, G. Tan, M. Teo, W. L. Goh, , S. B. Ng

bioRxiv · Nov 30, 2018 · PreprintMolecular Biology