P. De Los Rios

Autorepression of Yeast Hsp70 co-chaperones by intramolecular interactions involving their J-domains.

The paper investigates how J-domain proteins in yeast regulate Hsp70 chaperones through intramolecular interactions, showing auto-regulatory effects that reduce ATPase cycles.

The individual and combined benefits of differentnon-equilibrium proofreading mechanisms

The paper models non-equilibrium proofreading mechanisms to show that combining energy-consuming steps with substrate-dependent rate modulation improves selection accuracy and speed.

ABC Transporters are billion-year-old Maxwell Demons

This paper models ABC transporters as molecular Maxwell Demons, showing they use information processing to maintain concentration gradients through ATP hydrolysis.

Relief of ParB autoinhibition by parS DNA catalysis and ParB recycling by CTP hydrolysis promote bacterial centromere assembly.

This study investigates how CTP hydrolysis and parS DNA catalysis influence ParB clamp closure and recycling, contributing to bacterial centromere assembly.

Protein structure without structure determination: direct coupling analysis based on in vitro evolution

This study introduces a method to infer protein structure and evolutionary landscape from functional selection without direct structural determination or physical measurements.

DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes

The paper introduces a DNA-segment-capture model for SMC protein loop extrusion, predicting tension-dependent translocation velocity and step size.

Molecular chaperones inject energy from ATP hydrolysis into the non-equilibrium stabilisation of native proteins

The paper demonstrates that molecular chaperones use ATP hydrolysis energy to stabilize proteins in their active state under non-equilibrium conditions.