Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity
L. Cui, S.-Y. Chen, T. Lerbs, J.-W. Lee, P. Domizi, S. Gordon, Y.-h. Kim, G. P. Nolan, P. Betancur, G. Wernig
This study shows JUN activation in fibroblasts drives fibrosis and modulates immunity, with therapeutic potential through targeting IL-6, CD47, and PD-L1.
bioRxiv · Mar 18, 2020Immunology