Y.-H. Kim

Human bone tissue-derived ECM hydrogels: Controlling physicochemical, biochemical, and biological properties through processing parameters

This study shows that adjusting bone powder size and digestion time can improve the properties of human bone ECM hydrogels for bone tissue engineering.

Biofabrication of nanocomposite-based scaffolds containing human bone extracellular matrix for the differentiation of skeletal stem and progenitor cells

This paper develops a nanocomposite bioink using human bone extracellular matrix, nanoclay, and alginate for 3D bioprinting to support osteogenic differentiation of bone marrow stromal cells in vitro and ex vivo.

Sniper2L, a high-fidelity Cas9 variant with high activity

This paper develops Sniper2L, a high-fidelity Cas9 variant with improved specificity and retained high on-target activity, and introduces a deep-learning model to predict its activity.

Cardiac-Gated Spectroscopic Photoacoustic Imaging for Ablation-Induced Necrotic Lesion Visualization: In Vivo Demonstration in a Beating Heart

This paper demonstrates cardiac-gated spectroscopic photoacoustic imaging for visualizing ablation-induced necrotic lesions in a beating heart using a swine model.

Nementin is a Nematode-Selective Small Molecule Agonist of Neurotransmitter Release

A C. elegans-based screening pipeline identifies a selective nematicide that also potentiates acetylcholinesterase inhibitors.

Highly specific chimeric DNA-RNA guided genome editing with enhanced CRISPR-Cas12a system

The paper enhances CRISPR-Cas12a system specificity and efficiency using a chimeric DNA-RNA guide, achieving 7.41 and 7.60 times improvements respectively.

Expansion of the prime editing modality with Cas9 from Francisella novicida

This study expands prime editing by linking reverse transcriptase to FnCas9(H969A) nickase, enabling more precise and extended target gene modifications.

Epithelial Regeneration Ability of Crohn's Disease Assessed Using Patient-Derived Intestinal Organoids

This study assesses epithelial regeneration ability in Crohn's disease using patient-derived intestinal organoids and finds impaired regeneration, especially under TNF treatment.

Preprocessing of general stenotic vascular flow data for topological data analysis

This paper introduces a preprocessing method to adapt topological data analysis for general stenotic vascular geometries, enabling accurate analysis of vascular disease using persistent homology.

Gait analysis of healthy rhesus monkeys using a pressure-sensing walkway system

This study analyzed gait parameters of healthy rhesus monkeys using a pressure-sensing walkway, revealing forelimb dominance in weight distribution and symmetric gait patterns.

Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity

This study shows JUN activation in fibroblasts drives fibrosis and modulates immunity, with therapeutic potential through targeting IL-6, CD47, and PD-L1.

Highly Sensitive Identification of Lymphatic and Hematogenous Metastasis Routes of Novel Radiolabeled Exosomes Using Non-invasive PET Imaging

This study labels exosomes with radiotracers and uses PET imaging to track their lymphatic and hematogenous metastasis routes in mice.

Plant Growth-Promoting Activity of Beta-Propeller Protein YxaL Secreted from Bacillus velezensis Strain GH1-13

This study shows that YxaL, a secreted protein from Bacillus velezensis, promotes plant growth and stress tolerance in Arabidopsis, rice, and pepper.

Directed evolution of CRISPR-Cas9 to increase its specificity

This study evolves CRISPR-Cas9 to enhance specificity while maintaining on-target activity in human cells.

Reactive Oxygen Species Regulate the Inflammatory Function of NKT Cells through Promyelocytic Leukemia Zinc Finger

This study shows that reactive oxygen species (ROS) regulate NKT cell inflammatory functions via PLZF, with ROS levels differing between NKT and other T cell subsets.