Author

P. E. Czabotar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

G. Dewson· 2 shared G. Lessene· 2 shared A. E. Au· 1 shared A. L. Samson· 1 shared A. Riboldi-Tunnicliffe· 1 shared A. Sethi· 1 shared A. V. Jacobsen· 1 shared A. Wardak· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

G. Dewson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular definition of the BAK:VDAC2 interaction as a target to manipulate apoptosis

Z. Yuan, M. F. van Delft, M. X. Li, F. Sumardy, B. J. Smith, D. C. S. Huang, G. Lessene, Y. Khakham, R. Jin, S. He, N. A. Smith, R. Birkinshaw, P. E. Czabotar, G. Dewson

This study identifies key residues in the BAK:VDAC2 interaction, showing that disrupting this interaction can inhibit or promote apoptosis depending on the context.

bioRxiv · Dec 13, 2023 · PreprintCell Biology

Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL

A. Sethi, C. R. Horne, C. Fitzgibbon, K. L. Wilde, K. A. Davies, S. E. Garnish, A. V. Jacobsen, A. L. Samson, J. L. Hildebrand, A. Wardak, P. E. Czabotar, E. J. Petrie, P. R. Gooley, J. M. Murphy

The paper identifies distinct membrane binding epitopes in mouse and human MLKL orthologs that mediate necroptosis, revealing differences in their structural and functional mechanisms.

bioRxiv · May 3, 2021Cell Biology

Mechanism and inhibition of SARS-CoV-2 PLpro

T. Klemm, G. Ebert, D. J. Calleja, C. C. Allison, L. W. Richardson, J. P. Bernardini, B. G. C. Lu, N. W. Kuchel, C. Grohmann, Y. Shibata, Z. Y. Gan, J. P. Cooney, M. Doerflinger, A. E. Au, T. R. Blackmore, , D. Komander

This study investigates SARS-CoV-2 PLpro's mechanism and identifies non-covalent inhibitors with antiviral activity.

bioRxiv · Jun 18, 2020Biochemistry