Author

P. E. Lipsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

A. C. Grammer· 3 shared A. R. Daamen· 2 shared E. L. Hubbard· 2 shared P. Bachali· 2 shared A. C. Labonte· 1 shared A. Daamen· 1 shared A. Jabbari· 1 shared C. L. Mayberry· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersImmunology

A. C. Grammer

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Author profile →

4 papers

Recent·Most cited

Augmented glucose dependency of autoreactive B cells provides a treatment target forlupus

J. J. Wilson, J. Wei, A. R. Daamen, J. D. Sears, E. Bechtel, C. L. Mayberry, G. A. Stafford, L. Bechtold, A. C. Grammer, P. E. Lipsky, D. C. Roopenian, C.-H. Chang

This study identifies glycolysis-dependent autoreactive B cells as key mediators of lupus and shows that targeting them with 2DG or BCMA-specific CAR T-cells improves disease outcomes.

bioRxiv · Feb 1, 2022Immunology

The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus

T. M. Li, V. Zyulina, E. S. Seltzer, M. Dacic, Y. Chinenov, A. Daamen, K. R. Veiga, N. Schwartz, D. J. Oliver, J. Lora, A. Jabbari, Y. Liu, W. D. Shipman, W. G. Ambler, S. F. Taber, , T. T. Lu

This study shows that IFN-I in lupus skin reduces Langerhans cell ADAM17 activity, leading to increased photosensitivity, and that anti-IFNAR treatment restores ADAM17 function and reduces photosensitivity.

bioRxiv · Aug 18, 2021Immunology

Analysis of Gene Expression from Systemic Lupus Erythematosus Synovium Reveals a Profile of Activated Immune Cells and Inflammatory Pathways

E. L. Hubbard, M. D. Catalina, S. Heuer, P. Bachali, R. D. Robl, N. S. Geraci, A. C. Grammer, P. E. Lipsky

This study analyzes gene expression in SLE synovium to identify immune cell activation and inflammatory pathways, revealing potential therapeutic targets for lupus arthritis.

bioRxiv · Jun 19, 2020 · PreprintImmunology

Comprehensive Transcriptomic Analysis of COVID-19 Blood, Lung, and Airway

A. R. Daamen, P. Bachali, K. A. Owen, K. M. Kingsmore, E. L. Hubbard, A. C. Labonte, R. Robl, S. Shrotri, A. C. Grammer, P. E. Lipsky

This study analyzes gene expression in blood, lung, and airway tissues of COVID-19 patients to identify myeloid cell-driven inflammation and potential therapeutic targets.

bioRxiv · May 28, 2020Immunology