Paracoccin overexpression in Paracoccidioides brasiliensis reveals the influence of chitin hydrolysis on fungal virulence and host immune response
R. A. Goncales, V. C. S. Vieira, R. Ricci-Azevedo, F. F. Fernandes, S. M. d. O. Thomaz, A. Carvalho, P. E. Vendruscolo, C. Cunha, M. C. Roque-Barreira, F. Rodrigues
This study overexpresses paracoccin (PCN) in Paracoccidioides brasiliensis and finds that increased PCN levels enhance chitin hydrolysis, leading to smaller chitin particles that modulate host immune responses and increase fungal virulence.
bioRxiv · Jan 9, 2019 · PreprintMicrobiology