Author

R. A. Goncales

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:Arabidopsis· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:fungi (other)· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

A. Carvalho· 3 shared A. Rokas· 2 shared C. Duarte-Oliveira· 2 shared F. F. Fernandes· 2 shared F. Rodrigues· 2 shared G. H. Goldman· 2 shared J. L. Steenwyk· 2 shared M. C. Roque-Barreira· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersMicrobiology

A. Carvalho

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Author profile →

4 papers

Recent·Most cited

Paracoccin impacts on Paracoccidioides brasiliensis virulence and susceptibility to antifungal drugs by modifying the expression of genes related to remodeling of the yeasts cell wall

N. d. S. Pitangui, F. F. Fernandes, T. A. da Silva, R. A. Goncales, M. C. Roque-Barreira

This study shows that PCN overexpression increases virulence and antifungal susceptibility in P. brasiliensis, while silencing reduces virulence and increases resistance.

bioRxiv · Jul 5, 2022 · PreprintMicrobiology

Regulation of gliotoxin biosynthesis and protection in Aspergillus species

P. A. de Castro, M. Moraes, A. C. Colabardini, M. A. C. Horta, S. L. Knowles, H. A. Raja, N. H. Oberlies, Y. Koyama, M. Ogawa, K. Gomi, J. L. Steenwyk, A. Rokas, R. A. Goncales, C. Duarte-Oliveira, A. Carvalho, , G. H. Goldman

This study identifies conserved transcription factors and genes involved in gliotoxin protection in Aspergillus species through RNA-sequencing and deletion screening.

bioRxiv · Aug 16, 2021Microbiology

Aspergillus fumigatus acetate utilisation impacts virulence traits and pathogenicity

L. N. Ries, P. A. de Castro, L. P. Silva, C. Valero, T. F. dos Reis, R. Saborano, I. F. Duarte, G. F. Persinoti, J. L. Steenwyk, A. Rokas, F. Almeida, J. H. Costa, T. P. Fill, S. Sze Wah Wong, V. Aimanianda, , G. H. Goldman

This paper investigates how acetate utilization by Aspergillus fumigatus affects virulence traits and pathogenicity, showing its role in secondary metabolite secretion, cell wall composition, and in vivo virulence.

bioRxiv · Jun 9, 2021 · PreprintMicrobiology

Paracoccin overexpression in Paracoccidioides brasiliensis reveals the influence of chitin hydrolysis on fungal virulence and host immune response

R. A. Goncales, V. C. S. Vieira, R. Ricci-Azevedo, F. F. Fernandes, S. M. d. O. Thomaz, A. Carvalho, P. E. Vendruscolo, C. Cunha, M. C. Roque-Barreira, F. Rodrigues

This study overexpresses paracoccin (PCN) in Paracoccidioides brasiliensis and finds that increased PCN levels enhance chitin hydrolysis, leading to smaller chitin particles that modulate host immune responses and increase fungal virulence.

bioRxiv · Jan 9, 2019 · PreprintMicrobiology