Author

C. Cunha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 2 Immunology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:metagenomics· 2

Frequent Co-Authors

A. Carvalho· 2 shared A. Qvarnstrom· 2 shared C. Bergin· 2 shared C. F. Mugal· 2 shared J. C. Segami Marzal· 2 shared M. Semon· 2 shared A. A. Brakhage· 1 shared A. Campos· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

A. Carvalho

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Membrane fusion activity of herpes simplex virus 1 glycoproteins from a hyperfusogenic virus

K. A. Gianopulos, A. Makio, S. M. Pritchard, C. Cunha, M. Hull, A. V. Nicola

This study identifies hyperfusogenic mutations in HSV-1 glycoproteins gB, gD, and gH/gL from strain ANG, showing their role in enhanced membrane fusion and entry.

bioRxiv · Dec 4, 2023Microbiology

The genomic basis of hybrid male sterility in Ficedula flycatchers

J. C. Segami Marzal, C. F. Mugal, C. Cunha, C. Bergin, M. Schmitz, M. Semon, A. Qvarnstrom

The paper identifies candidate genes for hybrid male sterility in birds using genomic and transcriptomic data, revealing chromosomal and chromatin-related issues in hybrid spermatogenesis.

bioRxiv · Sep 19, 2022 · PreprintEvolutionary Biology

Metabolic profiling of drought tolerance: revealing how citrus rootstocks modulate plant metabolism under varying water availability

S. Silva, M. Miranda, C. Cunha, A. Domingues-Jr, J. Aricetti, C. Caldana, E. Machado, R. V. Ribeiro

This study investigates how Rangpur lime rootstocks modulate citrus metabolism under drought, identifying metabolic changes linked to drought tolerance.

bioRxiv · Jul 9, 2022Plant Biology

Single-Cell Transcriptomics reveals relaxed evolutionary constraint of spermatogenesis in two passerine birds as compared to mammals

J. C. Segami Marzal, M. Semon, C. Cunha, C. Bergin, C. F. Mugal, A. Qvarnstrom

This study uses single-cell transcriptomics to compare spermatogenesis in two passerine birds with mammals, finding relaxed evolutionary constraint in avian spermatocyte genes linked to ZW sex chromosomes.

bioRxiv · Jan 22, 2022 · PreprintEvolutionary Biology

Maternal γδ T Cells Shape Offspring Pulmonary Type-2 Immunity In A Microbiota-Dependent Manner

P. H. Papotto, B. Yilmaz, G. Pimenta, S. Mensurado, C. Cunha, G. J. Fiala, D. Gomes da Costa, N. Goncalves-Sousa, B. H. K. Chan, B. Blankenhaus, T. Carvalho, A. J. Macpherson, J. E. Allen, B. Silva-Santos

This study shows maternal γδ T cells influence offspring pulmonary type-2 immunity through microbiota-dependent mechanisms, affecting gut-lung axis development and inflammation.

bioRxiv · Aug 13, 2021Immunology

Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections

F. Schmidt, A. Thywissen, M. Röcker, C. Cunha, Z. Cseresnyes, H. Schmidt, S. Galiani, M. H. Gräler, G. Chamilos, J. F. Lacerda, A. Campos, C. Eggeling, T. Figge, T. Heinekamp, S. G. Filler, , A. A. Brakhage

This study shows that flotillin-dependent lipid rafts are essential for phagolysosomal function against fungal infections, with implications for human susceptibility to aspergillosis.

bioRxiv · Apr 12, 2019Microbiology

Paracoccin overexpression in Paracoccidioides brasiliensis reveals the influence of chitin hydrolysis on fungal virulence and host immune response

R. A. Goncales, V. C. S. Vieira, R. Ricci-Azevedo, F. F. Fernandes, S. M. d. O. Thomaz, A. Carvalho, P. E. Vendruscolo, C. Cunha, M. C. Roque-Barreira, F. Rodrigues

This study overexpresses paracoccin (PCN) in Paracoccidioides brasiliensis and finds that increased PCN levels enhance chitin hydrolysis, leading to smaller chitin particles that modulate host immune responses and increase fungal virulence.

bioRxiv · Jan 9, 2019 · PreprintMicrobiology