ImmunologybioRxiv
Leptospiral lipopolysaccharide dampens inflammation through upregulation of autophagy adaptor p62 and NRF2 signaling in macrophages
D. Bonhomme, I. Santecchia, P. Escoll Guerrero…·C. Werts
This study shows that leptospiral LPS activates p62 and NRF2 signaling in macrophages, reducing inflammation and aiding bacterial survival.