Author

I. Santecchia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Werts· 2 shared D. Bonhomme· 2 shared F. Vernel-Pauillac· 2 shared I. G. Boneca· 2 shared A. H. Williams· 1 shared A. Haouz· 1 shared A.-E. Deghmane· 1 shared B. Adler· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

C. Werts

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Leptospiral lipopolysaccharide dampens inflammation through upregulation of autophagy adaptor p62 and NRF2 signaling in macrophages

D. Bonhomme, I. Santecchia, P. Escoll Guerrero, F. Vernel-Pauillac, I. G. Boneca, C. Werts

This study shows that leptospiral LPS activates p62 and NRF2 signaling in macrophages, reducing inflammation and aiding bacterial survival.

bioRxiv · Aug 24, 2022Immunology

Leptospiral LPS escapes mouse TLR4 internalization and TRIF?associated antimicrobial responses through O antigen and associated lipoproteins

D. Bonhomme, I. Santecchia, F. Vernel-Pauillac, M. Caroff, P. Germon, G. Murray, B. Adler, I. G. Boneca, C. Werts

This study shows leptospiral LPS avoids triggering the TRIF-dependent antimicrobial response in mice by not internalizing TLR4, and this evasion depends on O antigen and co-purifying lipoproteins.

bioRxiv · May 18, 2020Immunology

Crippling the bacterial cell wall molecular machinery

A. H. Williams, I. Boneca, R. Wheeler, A.-E. Deghmane, I. Santecchia, F. Impens, P. A. D. Bastos, S. Hicham, M. Moya Nilges, C. Malosse, J. Chamot-Rooke, A. Haouz, W. P. Robins, M.-K. Taha

This study identifies the role of lytic transglycosylase LtgA in bacterial cell wall integrity and shows that targeting it can impair Neisseria meningitidis fitness during infection.

bioRxiv · Apr 12, 2019 · PreprintBiochemistry