Author

P. G. Marples

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 4 Organism:virus· 2 Approach:biophysical modeling· 1 Assay:protein structure· 1

Frequent Co-Authors

C. W. E. Tomlinson· 5 shared D. FearoniD· 5 shared A. V. Chandran· 4 shared F. von DelftiD· 4 shared L. KoekemoeriD· 4 shared M. FairheadiD· 4 shared M. Winokan· 4 shared W. Thompson· 4 shared

Activity by Year

2023-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersBiochemistry

C. W. E. Tomlinson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors

X. Ni, R. B. Richardson, A. S. de Godoy, M. P. Ferla, C. Kikawa, J. Scheen, W. W. Hannon, E. Capkin, N. Lahav, B. H. Balcomb, P. G. Marples, M. Fairhead, S. Wang, E. Williams, C. W. E. Tomlinson, , F. von Delft

The paper identifies fragment binders and mutationally intolerant sites in Zika virus NS2B-NS3 protease to develop resistance-resilient antiviral inhibitors.

bioRxiv · Apr 29, 2024 · PreprintBiochemistry

Crystallographic fragment screen of Enterovirus D68 3C protease and iterative design of lead-like compounds using structure-guided expansions

R. M. Lithgo, C. W. E. Tomlinson, M. Fairhead, M. Winokan, W. Thompson, C. Wild, J. Aschenbrenner, B. Balcomb, P. G. Marples, A. V. Chandran, M. N. Golding, L. Koekemoer, E. P. Williams, S. Wang, X. Ni, , F. von Delft

This study identifies fragments binding to EV-D68 3C protease through crystallography and expands them into lead-like compounds, revealing novel binding modes and structural insights for drug design.

bioRxiv · Apr 29, 2024 · PreprintBiochemistry

Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals

The paper identifies 75 fragments that bind to Coxsackievirus A16 2A protease, including 38 unique compounds in the active site, offering a path for broad-spectrum anti-enteroviral inhibitors.

bioRxiv · Apr 29, 2024 · PreprintBiochemistry

High-throughput crystallographic fragment screening of Zika virus NS3 Helicase

A. S. Godoy, N. C. M. R. Mesquita, C. Giroud, G. D. Noske, V. O. Gawriljuk, R. M. Lithgo, B. H. Balcomb, J. C. Aschenbrenner, C. W. E. Tomlinson, M. Winokan, J. Scheen, H. MacDermott-Opeskin, P. G. Marples, A. V. Chandran, X. Ni, , F. von Delft

This study uses high-throughput crystallographic fragment screening to identify 46 fragment binding poses on ZIKV NS3Hel, providing templates for antiviral drug design.

bioRxiv · Apr 27, 2024 · PreprintBiophysics

Targeting LC3/GABARAP for degrader development and autophagy modulation

M. P. Schwalm, J. Dopfer, A. Kumar, F. A. Greco, N. Bauer, F. Loehr, J. Heering, S. Cano, S. Lechner, T. Hanke, I. Bekic, V. Morasch, D. Fearon, P. G. Marples, C. W. E. Tomlinson, , V. V. Rogov

The paper evaluates the druggability of LC3/GABARAP for autophagy modulators and identifies ligands that bind to the HP2 pocket of the LIR docking site.

bioRxiv · Oct 5, 2023 · PreprintBiochemistry