Author

W. W. Hannon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Assay:proteomics· 3 Organism:virus· 3 Approach:experimental assay· 2 Research Focus:variant effect prediction· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. D. Bloom· 3 shared A. J. Greaney· 2 shared B. Dadonaite· 2 shared D. Veesler· 2 shared T. N. Starr· 2 shared A. C. Walls· 1 shared A. G. Farrell· 1 shared A. Ghez Farrell· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

J. D. Bloom

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike

B. Dadonaite, K. H. Crawford, C. E. Radford, A. G. Farrell, T. C. Yu, W. W. Hannon, P. Zhou, R. Andrabi, D. R. Burton, L. Liu, D. D. Ho, R. A. Neher, J. D. Bloom

This paper introduces a pseudovirus system for deep mutational scanning of SARS-CoV-2 spike protein mutations, showing how they affect antibody neutralization and infection.

bioRxiv · Oct 13, 2022Microbiology

Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains

T. N. Starr, A. J. Greaney, C. M. Stewart, A. C. Walls, W. W. Hannon, D. Veesler, J. D. Bloom

This study uses deep mutational scanning to analyze how mutations in the Omicron BA.1 and BA.2 RBDs affect ACE2 binding, RBD folding, and antibody escape, identifying epistatic shifts and lineage-specific changes.

bioRxiv · Sep 20, 2022Microbiology

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

T. N. Starr, A. J. Greaney, W. W. Hannon, A. N. Loes, K. Hauser, J. R. Dillen, E. Ferri, A. Ghez Farrell, B. Dadonaite, M. McCallum, K. A. Matreyek, D. Corti, D. Veesler, G. Snell, J. D. Bloom

The paper analyzes epistatic shifts in SARS-CoV-2 RBD mutations across variants to understand how they influence ACE2 binding and future evolution.

bioRxiv · Feb 24, 2022Microbiology