C. Giroud

Crystallographic fragment screen of Enterovirus D68 3C protease and iterative design of lead-like compounds using structure-guided expansions

This study identifies fragments binding to EV-D68 3C protease through crystallography and expands them into lead-like compounds, revealing novel binding modes and structural insights for drug design.

Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals

The paper identifies 75 fragments that bind to Coxsackievirus A16 2A protease, including 38 unique compounds in the active site, offering a path for broad-spectrum anti-enteroviral inhibitors.

High-throughput crystallographic fragment screening of Zika virus NS3 Helicase

This study uses high-throughput crystallographic fragment screening to identify 46 fragment binding poses on ZIKV NS3Hel, providing templates for antiviral drug design.

The lactonase BxdA mediates metabolic adaptation of maize root bacteria to benzoxazinoids

The paper identifies BxdA, a lactonase in maize root bacteria, which enables metabolic adaptation to benzoxazinoids, enhancing bacterial growth under carbon limitation.

Bacterial tolerance to host-exuded specialized metabolites structures the maize root microbiome

The paper shows that bacterial tolerance to benzoxazinoids, a type of plant specialized metabolite, determines their abundance in maize root microbiomes.