Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers
A. A. Cohen, Z. Yang, P. Gnanapragasam, S. Ou, K.-M. Dam, H. Wang, P. J. Bjorkman
This study constructs and characterizes influenza HA trimer-displaying nanoparticles and evaluates their immunogenicity, finding that mosaic particles do not consistently elicit broader immune responses than homotypic ones.
bioRxiv · Jan 18, 2020Immunology