Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells
C. Zhao, W. Wang, Y. Bai, G. Amonkar, H. Mou, J. Olejnik, A. J. Hume, E. Muhlberger, Y. Fang, J. Que, R. Fearns, X. Ai, P. H. Lerou
The paper shows that age-related STAT3 signaling impairment in neonatal bronchial epithelial cells increases RSV infection severity, while SARS-CoV-2 is unaffected by age.
bioRxiv · Sep 20, 2023 · PreprintCell Biology