Author

A. J. Hume

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Assay:bulk RNA-seq· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:whole-genome sequencing· 1

Frequent Co-Authors

E. Muhlberger· 4 shared F. Jakab· 3 shared G. E. Toth· 3 shared G. Kemenesi· 3 shared J. Olejnik· 3 shared A. A. Wilson· 2 shared A. Emili· 2 shared B. Zana· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersMicrobiology

E. Muhlberger

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells

C. Zhao, W. Wang, Y. Bai, G. Amonkar, H. Mou, J. Olejnik, A. J. Hume, E. Muhlberger, Y. Fang, J. Que, R. Fearns, X. Ai, P. H. Lerou

The paper shows that age-related STAT3 signaling impairment in neonatal bronchial epithelial cells increases RSV infection severity, while SARS-CoV-2 is unaffected by age.

bioRxiv · Sep 20, 2023 · PreprintCell Biology

Isolation and genome characterization of Lloviu virus from Italian Schreibers bent-winged bats

G. E. Toth, A. J. Hume, E. L. Suder, S. Zeghbib, A. Abraham, Z. Lanszki, Z. Varga, Z. Tauber, F. Foldes, B. Zana, D. Scaravelli, M. T. Scicluna, A. Pereswiet-Soltan, T. Gorfol, C. Terregino, , G. Kemenesi

The paper isolates and characterizes Lloviu virus from Italian bats, establishing an infectious isolate and conducting evolutionary analysis.

bioRxiv · Dec 5, 2022 · PreprintMicrobiology

The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters

L. Miorin, C. E. Mire, S. Ranjbar, A. J. Hume, J. Huang, N. A. Crossland, K. M. White, M. Laporte, T. Kehrer, V. Haridas, E. Moreno, A. Nambu, S. Jangra, A. Cupic, M. Dejosez, , A. E. Goldfeld

The paper shows that nitazoxanide inhibits SARS-CoV-2 replication and pathogenesis in human and hamster models, and synergizes with remdesivir against multiple variants.

bioRxiv · Feb 8, 2022 · PreprintImmunology

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV2 at the immune-epithelial interface

J. Leon, D. A. Michelson, J. Olejnik, K. Chowdhary, H. S. Oh, A. J. Hume, S. Galvan-Pena, Y. Zhu, F. Chen, B. Vijaykumar, L. Yang, E. Crestani, L. M. Yonker, D. M. Knipe, E. Muhlberger, C. Benoist

The paper investigates SARS-CoV2-induced inflammatory responses in monocytes using in vitro co-cultures, identifying a virus-specific gene cluster distinct from other viruses.

bioRxiv · Sep 29, 2021 · PreprintImmunology

Reservoir host studies of Lloviu virus: first isolation, sequencing and serology in Schreiber's bats in Europe

G. Kemenesi, G. E. Toth, M. Mayora-Neto, S. Scott, N. Temperton, E. Wright, E. Muhlberger, A. J. Hume, B. Zana, S. A. Boldogh, T. Gorfol, P. Estok, Z. Lanszki, B. A. Somogyi, A. Nagy, , F. Jakab

This study isolates and characterizes Lloviu virus from Schreiber's bats in Europe, showing its ability to infect human and monkey cells and suggesting potential spillover risks.

bioRxiv · Aug 10, 2021Microbiology

Recombinant Lloviu virus as a model to study inaccessible zoonotic viruses

A. J. Hume, B. Heiden, J. Olejnik, E. L. Suder, S. Ross, W. A. Scoon, E. Bullitt, M. Ericsson, M. R. White, J. Turcinovic, T. T. N. Thao, R. M. Hekman, J. E. Kaserman, J. Huang, K. Alysandratos, , E. Mühlberger

This study uses recombinant Lloviu virus to investigate replication mechanisms and host interactions of an uncultured filovirus related to Ebola.

bioRxiv · Aug 2, 2021 · PreprintMicrobiology

SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors

C. Gao, J. Zeng, N. Jia, K. Stavenhagen, Y. Matsumoto, H. Zhang, J. Li, A. J. Hume, E. Muehlberger, I. van Die, J. Kwan, K. Tantisira, A. Emili, R. D. Cummings

This study identifies multiple innate immune receptors that recognize SARS-CoV-2 spike protein through glycan-dependent interactions, suggesting potential therapeutic targets.

bioRxiv · Jul 29, 2020 · PreprintBiochemistry