Author

R. Fearns

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

E. Muhlberger· 2 shared A. J. Hume· 1 shared A. M. Burns· 1 shared A. M. Shareef· 1 shared B. J. Power· 1 shared C. Zhao· 1 shared D. A. Matthews· 1 shared D. Bhella· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCell Biology

E. Muhlberger

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells

C. Zhao, W. Wang, Y. Bai, G. Amonkar, H. Mou, J. Olejnik, A. J. Hume, E. Muhlberger, Y. Fang, J. Que, R. Fearns, X. Ai, P. H. Lerou

The paper shows that age-related STAT3 signaling impairment in neonatal bronchial epithelial cells increases RSV infection severity, while SARS-CoV-2 is unaffected by age.

bioRxiv · Sep 20, 2023 · PreprintCell Biology

DISTINCTIVE FEATURES OF THE RESPIRATORY SYNCYTIAL VIRUS PRIMING LOOP COMPARED TO OTHER NON-SEGMENTED NEGATIVE STRAND RNA VIRUSES

T. N. Cressey, A. M. Shareef, V. A. Kleiner, S. L. Noton, P. O. Byrne, J. S. McLellan, E. Muhlberger, R. Fearns

This study identifies Pro1261 in the RSV polymerase as critical for RNA synthesis initiation, unlike a corresponding residue in a filovirus polymerase.

bioRxiv · Mar 18, 2022Microbiology

Direct RNA sequencing of Respiratory Syncytial Virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance

I. Donovan Banfield, S. Hall, T. Gao, E. Murphy, J. Li, G. Shawli, J. A. Hiscox, R. Fearns, D. A. Matthews

This study uses direct RNA sequencing to analyze RSV mRNA transcripts in infected cells, revealing gene abundance patterns and polyadenylate tail lengths.

bioRxiv · Dec 23, 2021Microbiology

Helical Ordering of Envelope Associated Proteins and Glycoproteins in Respiratory Syncytial Virus Filamentous Virions

M. J. Conley, J. M. Short, J. Hutchings, A. M. Burns, J. Streetley, S. E. Bakker, H. Jaffery, M. Stewart, B. J. Power, G. Zanetti, R. Fearns, S. Vijayakrishnan, D. Bhella

This study uses cryoEM and cryoET to reveal helical symmetry in RSV virions, showing how M proteins and glycoproteins are organized and their implications for vaccine targets.

bioRxiv · Aug 4, 2021Microbiology