Author

P. J. Cossar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

C. Ottmann· 3 shared B. A. Somsen· 2 shared B. Tivon· 2 shared L. Brunsveld· 2 shared N. London· 2 shared R. Gabizon· 2 shared C. O. Ottmann· 1 shared D. K. Scott· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

C. Ottmann

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Author profile →

4 papers

Recent·Most cited

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.

L. S. Katz, E. J. Visser, K. F. Plitzko, M. Pennings, P. J. Cossar, I. L. Tse, M. Kaiser, L. Brunsveld, C. Ottmann, D. K. Scott

This paper identifies molecular glues that stabilize the ChREBP/14-3-3 complex, protecting beta cells from glucolipotoxicity by preventing ChREBP-mediated dedifferentiation.

bioRxiv · Feb 16, 2024Cell Biology

A simple method for developing lysine targeted covalent protein reagents

R. Gabizon, B. Tivon, R. N. Reddi, M. Van Den Oetelaar, H. Amartely, P. J. Cossar, C. Ottmann, N. London

This paper develops a method to create covalent protein reagents targeting lysine residues using methacrylate esters, demonstrating their effectiveness in binding and stabilizing protein complexes.

bioRxiv · Aug 28, 2023Biochemistry

Early identification of cooperative fragments for protein-protein interaction stabilization

P. J. de Vink, P. J. Cossar, B. A. Somsen, C. O. Ottmann, L. Brunsveld

The paper identifies cooperative fragments that stabilize protein-protein interactions using STD NMR and validates their effects through mutagenesis and crystallography.

bioRxiv · Feb 23, 2022 · PreprintBiochemistry

Covalent Flexible Peptide Docking in Rosetta

B. Tivon, R. Gabizon, B. A. Somsen, P. J. Cossar, C. Ottmann, N. London

The paper introduces CovPepDock, a computational pipeline for covalent peptide docking, and validates it by identifying potent electrophilic peptide binders.

bioRxiv · May 6, 2021Biochemistry