The p97-UBXN1 complex regulates aggresome formation
S. Mukkavalli, J. A. Klickstein, B. Ortiz, P. Juo, M. Raman
This study shows that the p97-UBXN1 complex is essential for aggresome formation and clearance, with UBXN1 specifically required for proper aggresome assembly and reduced polyQ aggregate formation in Huntington's disease models.
bioRxiv · Sep 3, 2020Cell Biology