Author

P. K. Jain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

L. T. Nguyen· 2 shared B. M. Smith· 1 shared E. K. Vesco· 1 shared G. M. Shoemaker· 1 shared K. S. Meister· 1 shared L. S. W. Sandoval· 1 shared N. C. Macaluso· 1 shared S. R. Rananaware· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 29 mutual co-author links

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2 shared papersBioengineering

L. T. Nguyen

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2 papers

Recent·Most cited

Programmable RNA detection with CRISPR-Cas12a

S. R. Rananaware, E. K. Vesco, G. M. Shoemaker, S. S. Anekar, L. S. W. Sandoval, K. S. Meister, N. C. Macaluso, L. T. Nguyen, P. K. Jain

This paper introduces SAHARA, a CRISPR-Cas12a-based method for direct RNA detection without reverse transcription, showing improved specificity and multiplexing capabilities.

bioRxiv · Jan 29, 2023Bioengineering

Enhancement of trans-cleavage activity of Cas12a with engineered crRNA enables amplified nucleic acid detection

L. T. Nguyen, B. M. Smith, P. K. Jain

This paper enhances Cas12a's trans-cleavage activity using engineered crRNAs, enabling sensitive nucleic acid detection without amplification, achieving femtomolar detection limits for DNA, RNA, and methylated DNA.

bioRxiv · Apr 13, 2020Bioengineering