L. T. Nguyen

Discovery of SARS-CoV-2 papain-like protease (PLpro) inhibitors with efficacy in a murine infection model

This study identifies potent SARS-CoV-2 PLpro inhibitors using machine learning, showing efficacy in a mouse model of COVID-19.

A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epithelium

This study identifies a rare progenitor cell population in the human airway that can differentiate into ionocytes or tuft cells, and shows cytokines can shift their lineage towards tuft cells in asthma and CF.

Programmable RNA detection with CRISPR-Cas12a

This paper introduces SAHARA, a CRISPR-Cas12a-based method for direct RNA detection without reverse transcription, showing improved specificity and multiplexing capabilities.

Sustained Delivery of GLP-1 Receptor Agonists from Injectable Biomimetic Hydrogels Improves Treatment of Diabetes

This paper develops a hydrogel-based GLP-1 receptor agonist delivery system that provides sustained therapy for up to 42 days in rats, improving diabetes management compared to daily injections.

Formulation excipients and their role in insulin stability and association state in formulation

This study investigates how excipients affect insulin stability and association state, finding that phenoxyethanol and specific copolymer concentrations enhance monomer content and stability in zinc-free insulin formulations.

An RNA binding protein, RNP1A, works with Contractility Kit proteins to facilitate macropinocytosis

This study identifies RNP1A as an RNA-binding protein that interacts with Contractility Kit proteins to support macropinocytosis in Dictyostelium discoideum.

Amplification of Olfactory Signals by Anoctamin 9 is Essential for Mammalian Olfaction: a Risk Factor for the Covid-19-associated Anosmia

This study identifies Anoctamin 9 as essential for mammalian olfaction, showing its role in amplifying olfactory signals and linking its downregulation to Covid-19-associated anosmia.

Ultra-fast insulin-pramlintide co-formulation for improved glucose management in diabetic rats

This study develops an ultra-fast insulin-pramlintide co-formulation that improves glucose management in diabetic rats by mimicking endogenous co-secretion and reducing patient burden.

Parental-fetal interplay of immune genes leads to intrauterine growth restriction

This study identifies a maternal-fetal immune interaction involving KIR2DL1 and HLA-C*05 that causes intrauterine growth restriction in a humanised mouse model.

Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer

The paper identifies immune hubs in colorectal cancer by analyzing transcriptional and spatial patterns in MMRd and MMRp tumors.

Natural Oil Blend Formulation (NOBF) as an anti- African Swine Fever Virus (ASFV) agent in Primary Porcine Alveolar Macrophases (PAM) cells of Swine

This paper tests a natural oil blend (NOBF) against ASFV in porcine alveolar macrophages, finding it deactivates the virus at high dilutions.

Optogenetic activation of heterotrimeric Gi proteins by LOV2GIVe - a rationally engineered modular protein

The paper introduces LOV2GIVe, a modular protein that optogenetically activates Gi proteins using blue light, offering a new tool for precise G-protein manipulation.

Immunomagnetic Sequential Ultrafiltration (iSUF) Platform for Enrichment and Purification of Extracellular Vesicles from Biofluids

The paper introduces an iSUF platform to enrich and purify tumor-derived extracellular vesicles from biofluids, showing high enrichment and biomarker expression in clinical samples.

Enhancement of trans-cleavage activity of Cas12a with engineered crRNA enables amplified nucleic acid detection

This paper enhances Cas12a's trans-cleavage activity using engineered crRNAs, enabling sensitive nucleic acid detection without amplification, achieving femtomolar detection limits for DNA, RNA, and methylated DNA.

Helicobacter small RNA regulates host adaptation and carcinogenesis

This study identifies HPnc4160, a small RNA in H. pylori, that negatively regulates host adaptation and gastric cancer by modulating gene expression and bacterial colonization.

Protein dynamics regulate distinct biochemical properties of cryptochromes in mammalian circadian rhythms

The paper identifies a dynamic loop in cryptochromes that regulates their differential binding to CLOCK:BMAL1, explaining their distinct roles in circadian rhythms.

Simulations of proposed mechanisms of FtsZ-driven cell constriction

This study simulates two models of FtsZ-driven bacterial cell constriction to determine which mechanisms can sustain constriction under turgor pressure.

Dynamic colonization of microbes and their functions after fecal microbiota transplantation for inflammatory bowel disease

This study profiles microbial colonization and immune function transfer after fecal microbiota transplantation in IBD, revealing dynamic competition and immune interactions that influence clinical outcomes.

Simulations suggest a constrictive force is required for Gram-negative bacterial cell division

The paper uses simulations to show that a constrictive force is needed for Gram-negative bacterial cell division, as cell wall remodeling alone is insufficient.

Complex models of sequence evolution require accurate estimators as exemplified with the invariable site plus Gamma model

The paper shows that the invariable site plus discrete Gamma model's parameters are poorly estimated by current software and proposes an improved optimization heuristic.

Structure of the fission yeast actomyosin ring during constriction

This study uses cryo-electron tomography to image the 3D structure of the actomyosin ring in fission yeast during cell division, revealing the arrangement of actin filaments.