Loss of ACKR4 in tumor cells dysregulates dendritic cell migration to tumor-draining lymph nodes and T-cell priming
D. Wangmo, P. K. Premsrirut, C. Yuan, W. S. Morris, X. Zhao, S. Subramanian
This study shows that loss of ACKR4 in colorectal cancer cells impairs dendritic cell migration and T-cell priming, leading to immune checkpoint blockade resistance.
bioRxiv · Aug 23, 2021Cancer Biology