C. Yuan

Chemokine receptor 5 signaling in PFC mediates stress susceptibility in female mice

This study shows that CCL5-CCR5 signaling in the prefrontal cortex of female mice contributes to stress susceptibility by altering microglia function and BBB integrity.

Single-cell transcriptomic landscape deciphers novel olfactory neuroblastoma subtypes and intratumoral heterogeneity

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

Polyethylene glycol (PEG)-associated immune responses triggered by clinically relevant lipid nanoparticles in rats

This study shows that LNP-based vaccines induce time- and dose-dependent anti-PEG antibodies in rats, with immune memory and accelerated blood clearance upon re-injection.

Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

This study shows that MFN2 deficiency leads to increased cytosolic Ca2+ and overactivation of RhoA and non-muscle myosin II, causing atypical peripheral actin band formation in mouse embryonic fibroblasts.

Intralumenal docking of Cx36 channels in the ER isolates mis-trafficked protein

The paper investigates how a dysfunctional PDZ binding motif in Cx36 affects its ER export and leads to ER retention and vesicle formation.

Loss of ACKR4 in tumor cells dysregulates dendritic cell migration to tumor-draining lymph nodes and T-cell priming

This study shows that loss of ACKR4 in colorectal cancer cells impairs dendritic cell migration and T-cell priming, leading to immune checkpoint blockade resistance.

miR-206 inhibits estrogen-induced proliferation and invasion of ER-α36 positive gastric cancer cells

This study shows miR-206 reduces estrogen-induced proliferation and invasion of ER-α36 positive gastric cancer cells by targeting CDK14.

Interactive regulation between aliphatic hydroxylation and aromatic hydroxylation of thaxtomin D in TxtC, a theoretical investigation

This paper investigates how TxtC catalyzes sequential hydroxylation of thaxtomin D, revealing that aliphatic hydroxylation is preferred due to lower energy barriers and conformational changes induced by intermediate hydroxyl groups.

Role of 1'-Ribose Cyano Substitution for Remdesivir to Effectively Inhibit both Nucleotide Addition and Proofreading in SARS-CoV-2 Viral RNA Replication

This study uses molecular dynamics simulations to show that Remdesivir's 1-cyano group inhibits SARS-CoV-2 RdRp by disrupting nucleotide addition and proofreading, providing insights for drug design.

Tumor secreted extracellular vesicles regulate T-cell costimulation and can be manipulated to induce tumor-specific T-cell responses

This study shows that tumor-secreted extracellular vesicles suppress T-cell costimulation and that modifying these vesicles can enhance antitumor immune responses and improve immunotherapy effectiveness.

Morphological and physiological response strategies of Vallisneria natans at different water depths and light conditions

This study investigates how water depth and light conditions affect the morphology, physiology, and resource allocation of Vallisneria natans, showing shifts in resource allocation between light acquisition and reproduction.

Incorporating trait-based mechanisms, alternative interaction modes and forbidden links increases the minimum trait dimensionality of ecological networks

This paper introduces a method to estimate the minimum trait dimensionality of ecological networks by incorporating trait-based mechanisms, alternative interaction modes, and forbidden links, showing it increases dimensionality estimates compared to existing methods.

Integrated Analysis of Methylome and Transcriptome Following Developmental Atrazine Exposure in Zebrafish Reveals Aberrant Gene-Specific Methylation of Neuroendocrine and Reproductive Pathways

This study examines the effects of atrazine exposure on DNA methylation and gene expression in zebrafish, identifying specific genes and pathways affected by the herbicide.

PulseDIA: in-depth data independent acquisition mass spectrometry using enhanced gas phase fractionation

PulseDIA improves DIA-MS specificity and sensitivity by using gas phase fractionation, achieving higher protein identification rates in cancer proteomics.

Biocontrol of PGPR strain Bacillus amyloliquefaciens Ba168 against Phytophthora nicotianae on tobacco

This paper evaluates the biocontrol potential of PGPR strain Ba168 against tobacco black shank caused by Phytophthora nicotianae, showing it is effective but slightly less than a chemical mixture.

Analysis of LRRC45 indicates cooperative functions of distal appendages at early steps of ciliogenesis

This study identifies LRRC45's role in ciliogenesis by showing it recruits FBF1 to the mother centriole and promotes cilia biogenesis in CP110-uncapped centrioles.