Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs
T. A. Edwards, J. A. Miles, F. Hobor, J. L. Taylor, C. Tiede, P. L. Rowell, C. H. Trinh, B. R. Jackson, F. A. Nadat, H. F. Kyle, B. I. Wicky, J. Clarke, D. C. Tomlinson, A. J. Wilson
The paper identifies Affimer reagents that selectively bind BCL-2 family proteins through non-canonical structural motifs, showing competitive inhibition and conformational changes.
bioRxiv · May 27, 2019 · PreprintBiochemistry