Author

T. A. Edwards

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1

Frequent Co-Authors

A. J. Wilson· 2 shared F. Hobor· 2 shared A. A. Ibarra· 1 shared A. A. Macdonald· 1 shared B. Alvarez-Rodriguez· 1 shared B. I. Wicky· 1 shared B. R. Jackson· 1 shared C. H. Trinh· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

A. J. Wilson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The cryoEM structure of the Hendra henipavirus nucleoprotein reveals insights into paramyxoviral nucleocapsid architectures

T. C. Passchier, J. B. R. White, D. P. Maskell, M. J. Byrne, N. A. Ranson, T. A. Edwards, J. N. Barr

The paper reports the cryoEM structure of Hendra henipavirus nucleoprotein bound to RNA, revealing unique interactions in its multimeric assembly and insights into paramyxoviral nucleocapsid architecture.

bioRxiv · Dec 7, 2023 · PreprintMicrobiology

The virus-encoded ion channel "viroporin" activity of the agnoprotein is required for BK Polyomavirus release from infected kidney cells

G. Swinscoe, E. L. Prescott, D. L. Hurdiss, E. L. Morgan, S. J. Dobson, T. A. Edwards, R. Foster, M. Welberry-Smith, A. A. Macdonald

This study identifies agnoprotein as a viroporin required for BK polyomavirus release from infected cells and identifies small molecules that inhibit its activity.

bioRxiv · Jan 30, 2023 · PreprintMicrobiology

Understanding p300-transcription factor interactions using sequence variation and hybridization

F. Hobor, Z. Hegedus, A. A. Ibarra, V. L. Petrovicz, G. J. Bartlett, R. B. Sessions, A. J. Wilson, T. A. Edwards

The paper investigates HIF-1 sequence variation tolerance using biochemical assays, showing that sequence changes are tolerated through disordered binding interactions.

bioRxiv · Dec 16, 2021Biochemistry

The structure of a native orthobunyavirus ribonucleoprotein reveals a key role for viral RNA in maintaining its helical architecture

F. Hopkins, B. Alvarez-Rodriguez, G. Heath, K. Panayi, S. Hover, T. A. Edwards, J. Barr, J. Fontana

This paper determines the 3D structure of a native bunyavirus ribonucleoprotein (RNP) using cryo-EM, revealing a helical architecture stabilized by RNA rather than longitudinal contacts between nucleoprotein monomers.

bioRxiv · Oct 27, 2021 · PreprintMicrobiology

Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs

T. A. Edwards, J. A. Miles, F. Hobor, J. L. Taylor, C. Tiede, P. L. Rowell, C. H. Trinh, B. R. Jackson, F. A. Nadat, H. F. Kyle, B. I. Wicky, J. Clarke, D. C. Tomlinson, A. J. Wilson

The paper identifies Affimer reagents that selectively bind BCL-2 family proteins through non-canonical structural motifs, showing competitive inhibition and conformational changes.

bioRxiv · May 27, 2019 · PreprintBiochemistry