Author

P. Lobel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

D. E. Sleat· 2 shared A. M. Collier· 1 shared A. Majumdar· 1 shared A. Modak· 1 shared D. L. Cruz· 1 shared F. R. Maxfield· 1 shared M. El-Banna· 1 shared M. Muldowney· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

D. E. Sleat

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Author profile →

2 papers

Recent·Most cited

Lysosomal enzyme tripeptidyl peptidase 1 plays a role in degradation of beta amyloid fibrils

D. L. Cruz, M. El-Banna, A. Majumdar, D. E. Sleat, M. Muldowney, P. Lobel, F. R. Maxfield

This study shows that TPP1 promotes fibrillar β-amyloid degradation in microglia and that reducing TPP1 increases amyloid plaque burden in an AD mouse model.

bioRxiv · Dec 6, 2020 · PreprintCell Biology

Protein thermal stability does not correlate with cellular half-life: Global observations and a case study of tripeptidyl-peptidase 1

A. M. Collier, Y. Nemtsova, N. Kuber, W. Banach-Petrosky, A. Modak, D. E. Sleat, V. Nanda, P. Lobel

This study shows that increasing the thermal stability of TPP1 does not improve its cellular half-life, suggesting that in vitro stability metrics may not predict physiological stability.

bioRxiv · Nov 11, 2019Biochemistry