Author

F. R. Maxfield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:imaging· 2

Frequent Co-Authors

A. S. Haka· 2 shared N. H. Pipalia· 2 shared A. Al-Motawa· 1 shared A. Asmal· 1 shared A. Cross· 1 shared A. Majumdar· 1 shared B. Blagg· 1 shared C. P. Horoszko· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

A. S. Haka

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Author profile →

5 papers

Recent·Most cited

Real-Time Ratiometric pH Imaging of Macrophage Lysosomes Using the Novel pH-sensitive Probe ApHID.

S. Sole-Domenech, P. Kumar Singh, J. D. Warren, F. R. Maxfield

The paper introduces a novel pH-sensitive probe, ApHID, for real-time ratiometric pH imaging of macrophage lysosomes, showing improved performance over existing probes.

bioRxiv · Jan 20, 2024 · PreprintBiochemistry

HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts

N. H. Pipalia, S. Z. Saad, K. Subramanian, A. Cross, A. Al-Motawa, K. K. Garg, B. Blagg, L. Neckers, P. Helquist, O. Wiest, D. S. Ory, F. R. Maxfield

This study shows HSP90 inhibitors reduce cholesterol storage in NPC1 mutant fibroblasts by enhancing mutant NPC1 protein delivery to lysosomes.

bioRxiv · Apr 22, 2021Cell Biology

Lysosomal enzyme tripeptidyl peptidase 1 plays a role in degradation of beta amyloid fibrils

D. L. Cruz, M. El-Banna, A. Majumdar, D. E. Sleat, M. Muldowney, P. Lobel, F. R. Maxfield

This study shows that TPP1 promotes fibrillar β-amyloid degradation in microglia and that reducing TPP1 increases amyloid plaque burden in an AD mouse model.

bioRxiv · Dec 6, 2020 · PreprintCell Biology

TLR4-dependent signaling drives extracellular catabolism of low-density lipoprotein aggregates

R. K. Singh, A. S. Haka, A. Asmal, V. C. Barbosa-Lorenzi, I. Grosheva, H. F. Chin, Y. Xiong, T. Hla, F. R. Maxfield

This study shows TLR4 signaling promotes extracellular catabolism of LDL aggregates and lipid accumulation in macrophages through lysosomal synapse formation.

bioRxiv · Apr 15, 2019 · PreprintCell Biology

A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux

P. V. Jena, D. Roxbury, T. V. Galassi, L. Akkari, C. P. Horoszko, D. B. Iaea, J. Budhathoki-Uprety, N. H. Pipalia, A. S. Haka, J. D. Harvey, J. Mittal, F. R. Maxfield, J. A. Joyce, D. A. Heller

This paper develops an optical reporter using carbon nanotubes to measure endolysosomal lipid flux in live cells, revealing lipid accumulation in disease models and sub-cellular heterogeneity.

bioRxiv · Aug 28, 2017Bioengineering