Author

S. R. Cleary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Assay:proteomics· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

S. L. Robia· 4 shared E. E. Cho· 3 shared J. Seflova· 3 shared X. Fang· 3 shared L. M. Espinoza-Fonseca· 2 shared P. M. Kekenes-Huskey· 2 shared A. C. Teng· 1 shared A. Deyawe Kongmeneck· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersBiophysics

S. L. Robia

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Phospholamban Inhibits the Cardiac Calcium Pump Through Reversing the Allosteric Enhancement of Calcium Affinity by ATP

S. R. Cleary, J. Seflova, E. E. Cho, K. Bisht, H. Khandelia, L. M. Espinoza-Fonseca, S. L. Robia

This paper investigates how phospholamban (PLB) inhibits the cardiac calcium pump SERCA by reversing ATP-induced allosteric enhancement of calcium affinity, using biochemical assays and structural analysis.

bioRxiv · Jul 20, 2023 · PreprintBiochemistry

Dilated cardiomyopathy variant R14del increases phospholamban pentamer stability, blunting dynamic regulation of cardiac calcium handling

S. R. Cleary, A. C. Teng, A. Deyawe Kongmeneck, X. Fang, T. A. Phillips, E. E. Cho, P. M. Kekenes-Huskey, A. O. Gramolini, S. L. Robia

This study shows that the R14del mutation in phospholamban increases pentamer stability, reducing its ability to regulate SERCA and impairing cardiac calcium handling during physiological stress.

bioRxiv · May 26, 2023 · PreprintPhysiology

STOICHIOMETRY OF THE SODIUM PUMP-PHOSPHOLEMMAN REGULATORY COMPLEX

J. Seflova, N. R. Habibi, J. Q. Yap, S. R. Cleary, X. Fang, P. M. Kekenes-Huskey, L. M. Espinoza-Fonseca, J. B. Bossuyt, S. L. Robia

The paper investigates the stoichiometry and structure of the NKA-PLM regulatory complex using fluorescence lifetime assays and simulations, revealing a (alpha-beta-PLM)2 composition.

bioRxiv · Oct 12, 2021 · PreprintBiophysics

Inhibitory and Stimulatory Micropeptides Preferentially Bind to Different Conformations of the Cardiac Calcium Pump

S. R. Cleary, X. Fang, E. E. Cho, M. P. Pribadi, J. Seflova, J. R. Beach, P. Kekenes-Huskey, S. L. Robia

The paper shows that inhibitory and stimulatory micropeptides bind to different conformations of the cardiac calcium pump SERCA, with their binding preference depending on intracellular Ca2+ levels.

bioRxiv · Jun 15, 2021Biophysics