Rational Designed Hybrid Peptides Show up to a 6-fold Increase in Antimicrobial Activity and Demonstrate Different Ultrastructural Changes as the Parental Peptides measured by BioSAXS
K. Hilpert, J. Gani, C. Rumancev, N. Simpson, P. M. Lopez-Perez, V. M. Garamus, A. R. vonGundlach, P. Markov, M. Scocchi, R. Mikut, A. Rosenhahn
The paper designs hybrid peptides combining proline-rich and arginine-isoleucine-rich peptides, showing up to 6-fold increased antimicrobial activity and distinct structural effects compared to parental peptides.
bioRxiv · Nov 5, 2021Microbiology