Author

R. Mikut

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biophysics· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Organism:bacteria (other)· 2 Approach:deep learning· 2 Organism:human· 2 Assay:metagenomics· 2

Frequent Co-Authors

K. Hilpert· 6 shared A. Rosenhahn· 3 shared C. Rumancev· 3 shared J. Gani· 3 shared P. M. Lopez-Perez· 3 shared V. M. Garamus· 3 shared A. Cookson· 2 shared H. Vallin· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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6 shared papersMicrobiology

K. Hilpert

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Can BioSAXS Detect Ultrastructural Changes Of Antifungal Compounds In Candida Albicans? - An Exploratory Study

K. Hilpert, C. Rumancev, J. Gani, D. W. P. Collis, P. M. Lopez-Perez, V. M. Garamus, R. Mikut, A. Rosenhahn

This study explores whether BioSAXS can detect ultrastructural changes in Candida albicans caused by antifungal compounds, showing separation between treated and untreated cells using PCA.

bioRxiv · May 12, 2023 · PreprintMicrobiology

Synchronization of oscillatory growth prepares fungal hyphae for fusion

V. Wernet, V. Kumpost, R. Mikut, L. Hilbert, R. Fischer

This paper shows fungal hyphae use oscillatory signaling and calcium-dependent growth to prepare for cell fusion, transitioning from individual 'monologue' to coordinated 'dialogue' when interacting.

bioRxiv · Sep 25, 2022Cell Biology

Characterization of the Pace-and-Drive Capacity of the Human Sinoatrial Node: a 3D in silico Study

A. Amsaleg, J. Sanchez, R. Mikut, A. Loewe

This study uses a 3D in silico model of the human sinoatrial node to investigate how its structure and electrophysiological properties enable successful pacing and driving of the heart.

bioRxiv · Jun 3, 2022Physiology

Rational Designed Hybrid Peptides Show up to a 6-fold Increase in Antimicrobial Activity and Demonstrate Different Ultrastructural Changes as the Parental Peptides measured by BioSAXS

K. Hilpert, J. Gani, C. Rumancev, N. Simpson, P. M. Lopez-Perez, V. M. Garamus, A. R. vonGundlach, P. Markov, M. Scocchi, R. Mikut, A. Rosenhahn

The paper designs hybrid peptides combining proline-rich and arginine-isoleucine-rich peptides, showing up to 6-fold increased antimicrobial activity and distinct structural effects compared to parental peptides.

bioRxiv · Nov 5, 2021Microbiology

Synergy pattern of short cationic antimicrobial peptides against multidrug-resistant Pseudomonas aeruginosa

S. Ruden, A. Rieder, T. Schwartz, R. Mikut, K. Hilpert

The paper tests synergistic effects of 30 short AMPs with antibiotics against multidrug-resistant Pseudomonas aeruginosa, finding synergistic combinations with Polymyxin B, Erythromycin, and Tetracycline.

bioRxiv · May 17, 2019Microbiology

BioSAXS measurements reveal that two antimicrobial peptides induce similar molecular changes in Gram-negative and Gram-positive bacteria

A. von Gundlach, M. Ashby, J. Gani, P. M. Lopez-Perez, A. Cookson, S. Huws, C. Rumancev, V. M. Garamus, R. Mikut, A. Rosenhahn, K. Hilpert

This paper uses BioSAXS and EM to show that two antimicrobial peptides induce similar structural changes in Gram-negative and Gram-positive bacteria, suggesting a common mode of action.

bioRxiv · Apr 17, 2019Biophysics

In silico identification of novel peptides with antibacterial activity against multidrug resistant Staphylococcus aureus

L. B. Oyama, H. Olleik, A. C. N. Teixeira, M. M. Guidini, J. A. Pickup, A. R. Cookson, H. Vallin, T. Wilkinson, D. Bazzolli, J. Richards, M. Wootton, R. Mikut, K. Hilpert, M. Maresca, J. Perrier, , S. A. Huws

This study identifies two novel antimicrobial peptides, HG2 and HG4, effective against multidrug-resistant Staphylococcus aureus using in silico methods and experimental validation.

bioRxiv · Mar 13, 2019Microbiology

The rumen microbiome: an underexplored resource for novel antimicrobial discovery

L. B. Oyama, S. Girdwood, A. Cookson, N. Fernandez-Fuentes, F. Prive, H. Vallin, T. Wilkinson, P. Golyshin, O. Golyshina, R. Mikut, K. Hilpert, J. Richards, M. Wootton, J. Edwards, M. Maresca, , S. A. Huws

The paper identifies novel antimicrobial peptides from the rumen microbiome and demonstrates their efficacy against MRSA in vitro and in a mouse model.

bioRxiv · Jul 12, 2017Microbiology